The reproductive health of American adolescents has been, and continues to be, a matter of serious concern. America's teen birth rate--already one of the highest among developed nations--is again on the rise. Also, rates of sexually-transmitted infection (STI) among teens remain disconcertingly high, with one-quarter of the 19 million new cases of STIs each year occurring to 15- to 19-year-olds. In 2006, there were nearly 442,000 births to adolescents under the age of 20. Many out-of-school time programs serving adolescents seek to reduce the occurrence of reproductive health problems, such as pregnancies and STIs, among program participants. Other programs, even if not directly concerned with improving participants' reproductive health, can still be attuned to reproductive health issues facing adolescents and may wish to monitor participant health and sexual risk-taking. This brief discusses adolescent reproductive health and provides program practitioners with questions that can be used to screen or monitor reproductive health among out-of-school time program participants. (Contains 46 endnotes.)