"The Challenge" provides information and resources to help schools create safe and healthy learning environments for students. Articles in this issue include: (1) Research Shows Consequences of Drug Abuse on the Teenage Brain (Don Vereen); (2) Interview: NIDA [National Institute on Drug Abuse] Director Discusses Drug Abuse among Teens; (3) Know the Warning Signs of Teen Drug Use; and (4) Programs to Prevent Drug Abuse: One Size Does Not Fit All. OSDFS Grants Forecast for Fiscal Year 2007, recent research findings, and resources for finding more information are also included. ["The Challenge" is published by the U.S. Department of Education's Office of Safe and Drug-Free Schools. For "The Challenge. Volume 14, Number 2," see ED494849.]