This guide is intended to share knowledge about the Hispanic/Latino community with Center for Substance Abuse Prevention (CSAP) grant recipients and to help them develop effective prevention services responsive to the communities they serve. The guide: (1) highlights specific characteristics of the Hispanic and Latino communities that affect prevention strategies; (2) defines natural support systems and describes how their integration with conventional prevention practice can improve the prevention program; and (3) helps grantees identify, assess, and access natural resources in the communities. Because of distinct cultural values and orientations, the Hispanic/Latino community benefits most from culturally sensitive prevention programs that incorporate both formal and informal sources of support. An inclusive and integrated approach capitalizes on the strengths of the community it serves. The most effective alcohol, tobacco, and other drug use prevention programs must be planned, organized, and implemented in full partnership with the community. A bibliography of 14 publications and a list of 11 organizational resources are included, along with a list of 28 CSAP grant recipients by state. (Contains three exhibits, two sample maps, and five references.) (SLD)