A lecture given in courses in applied pharmacokinetics at Wayne State University, Michigan, is presented. The definition of bioavailability is reviewed along with methods of calculation, bioequivalence, criteria for establishing bioequivalence of a new product, essentials of a bioequivalence study, and the relationship between bioequivalence and…

Reviews much of what is known about microtubules, which are biopolymers consisting predominantly of subunits of the globular protein, tubulin. Describes the functions of microtubules, their structure and assembly, microtube associated proteins, and microtubule-disrupting agents. (TW)

Discusses major uses of rats as experimental animals for studying health concerns, pointing out that their size, gestation, and histocompatibility make them useful in various studies. Topic areas addressed include aging, autoimmune disease, genetics, cancer, diabetes, hypertension, infection, reproduction, and behavior. (DH)

Defines biological engineering and discusses why it is needed. Lists some interesting areas of biological engineering. Presents a table of four phases of scientific disciplines. (YP)

Describes a computer simulation program which helps students learn the main biochemical tests and profiles for identifying medically important bacteria. Also discusses the advantages and applications of this type of approach. (ML)

Traces the history of using mice for medical research and discusses the benefits of using these animals for studies in bacteriology, virology, genetics (considering X-linked genetic homologies between mice and humans), molecular biology, immunology, hematology, immune response disorders, oncology, radiobiology, pharmacology, behavior genetics,…

Presents an introduction to the Biochemical and Biomedical Engineering program at Rice University. Describes the development of the academic and enhancement programs, including organizational structure and research project titles. (YP)

The advantages and justifications for using small animals in human-oriented research are reviewed. Some of the pitfalls of extrapolating animal-derived data to humans are discussed. Several specific problems with animal experimentation are highlighted. (CW)

Describes a college course designed to explicate the political dimensions of biomedical issues now emerging in American society. The course combines a rigorous overview of the technologies and the accompanying value changes which are producing these issues with a discussion of the problems being raised. (RM)

Describes the use of a short, fictional story about a woman's surgery to illustrate issues and promote discussion about biomedical ethics, particularly the issue of informed consent. Discussion connects the personal story with specific litigation, comparing legal requirements and ethical responsibility in physician-patient communication. (MSE)

Provides a review of science news stories reported in "Science News" during 1987. References each item to the volume and page number in which the subject was addressed. Contains references on astronomy, behavior, biology, biomedicine, chemistry, earth sciences, environment, mathematics and computers, paleontology and anthropology, physics, science…

Reviews the copyright problems involved in interlibrary loans using photocopies of journal articles and describes the development of a document delivery system, in which materials are stored on optical disks, printed on demand, and a copyright fee is included in pricing. Technical and practical aspects of the system are discussed. (CLB)

The need to give high school students a more pragmatic grasp and understanding of technology, in addition to guidance concerning their career paths, is discussed. Described are the design, initiation, methods, topics and evaluation of this exploratory program. Recommendations for future implementation of similar programs are provided. (CW)

Described is a capstone experience for undergraduate biomedical engineering students in which student teams work with children and adults with cerebral palsy to produce devices that make their lives easier or more enjoyable. The collaborative approach, benefits to the clients, and evaluation of the projects are discussed. (CW)

Existing federal government policies and systems to protect against scientific misconduct in government-supported research projects are described, and additional considerations not covered in federal policy are enumerated. Misconduct inquiries and review procedures are outlined. Applicant and institutional responsibility and the role of prevention…