Historically Black Colleges and Universities (HBCU) play an important and unique role in the higher education system. For example, more than one-third of African-Americans who received a doctorate in science, technology, engineering, or mathematics in 2016 obtained their undergraduate degrees from an HBCU, and many also received their doctorates from an HBCU. As of December 2018, there were 101 HBCUs. The White House Initiative on HBCUs was established in 1980 as a government-wide effort to strengthen the capacity of HBCUs, including their ability to participate in federal programs. The Small Business Administration's (SBA) mission is to help Americans start, build, and grow businesses, among other things. SBA also works with public- and private-sector partners, including colleges and universities, to strengthen or expand businesses development and foster entrepreneurship. For example, public or private institutions of higher education can host Small Business Development Centers (SBDC), which provide technical assistance to existing small businesses and aspiring entrepreneurs. SBA also fosters working relationships with institutions of higher education through memorandums and outreach activities (such as training and counseling). However, little is known about the extent of SBA's activities and partnership programs with HBCUs. This report examines (1) federal priorities and SBA goals related to working with HBCUs; and (2) SBA's key programs and outreach activities for fostering entrepreneurship, particularly with HBCUs, and what is known about HBCU participation in these programs and activities. [Major contributors to this report include Lisa Moore, Chir-Jen Huang, Rachel Beers, Benjamin Licht, Sulayman Njie, Barbara Roesmann, Jessica Sandler, Jena Sinkfield, and Andrew Stavisky.]