Taking risks is fairly common in adolescence. Risky behaviors can be associated with serious, long-term, and--in some cases--life-threatening consequences. This is especially the case when adolescents engage in more than one harmful behavior. The tendency for risky behaviors to co-occur has been well-studied. Yet prevention efforts traditionally have taken a targeted approach, seeking to prevent a single risky behavior. A more powerful and cost-effective approach may be to employ strategies designed to address factors associated with "multiple" risky behaviors. This "Research Brief" brings together findings from developmental science and from rigorous program evaluations to identify seven actionable, feasible strategies and relevant programs that have been found to affect two or more risky behaviors. These strategies are to: (1) Support and strengthen family functioning; (2) Increase connections between students and their schools; (3) Make communities safe and supportive for children and youth; (4) Promote involvement in high quality out-of-school-time programs; (5) Promote the development of sustained relationships with caring adults; (6) Provide children and youth opportunities to build social and emotional competence; and (7) Provide children and youth with high quality education during early and middle childhood. (Contains 1 table, 2 footnotes and 99 endnotes.)