This guide addresses the challenge of inaccessible digital learning resources by providing K-12 education stakeholders with actionable information about EPUB, a digital file format. EPUB is a widely adopted format for many digital books and is specifically designed to display text, audio, images and, in some cases, video in a manner usable by all learners, especially those with sensory, physical and learning disabilities including those who use assistive technology (AT). For these students, the ability to personalize the format of learning materials is essential; and for all students, EPUB simply provides more options: it can be more accessible, in more ways, than any other format. EPUB has been fully embraced by higher education publishers, and K-12 publishers are now starting to modify their publishing workflows to create EPUB content. Users of this guide will learn how apps (reading systems) can personalize the reading experience, which benefits everybody. It also details how students with reading difficulties can benefit from the rich range of accessibility features built into the EPUB format and into apps. Teachers and curriculum development professionals will learn how to use common word processing software to create their own fully accessible materials as EPUBs. [This report was co-prepared by the DAISY Consortium and Bookshare.]