Research has identified educational and career development interventions that can make a positive difference in the lives of youth. Work-based learning experiences, preferably connected to curriculum content; student-centered individualized education programs that drive instruction; family involvement in and support of education and career development activities; and linkages to individually determined support services have all been proven, by both practice and research, to lead to the education and employment success of all youth, including youth with disabilities. All youth need: (1) Access to high quality standards-based education regardless of the setting; (2) Information about career options and exposure to the world of work, including structured internships; (3) Opportunities to develop social, civic, and leadership skills; (4) Strong connections to caring adults; (5) Access to safe places to interact with their peers; and (6) Support services to allow them to become independent adults. The National Collaborative on Workforce & Disability for Youth (NCWD/Youth) has identified Guideposts for Success based on what research indicates that all youth need to transition to adulthood successfully. The Guideposts provide: (1) a statement of principles; (2) a direction that will lead to better outcomes for all young people; and (3) a way to organize policy and practice. After providing a detailed list within each Guidepost of what all youth need, the framework then describes additional specific needs pertaining to youth with disabilities. By addressing these specific needs policymakers, program administrators, youth service practitioners, parents, family members, and youth will have access to a foundation that will lead to work, further education, and independent community living.