Long-standing systemic health and social inequities have put Latino families, and other racial and ethnic minority groups, at increased risk of contracting COVID-19. The disproportionate impact of COVID-19 on the Latino community threatens to undermine the educational progress of more than 13 million Latino students and five million English learners in K-12 public schools. As state education agencies and school districts continue to develop their school reopening guidance, UnidosUS shares a framework of guiding questions and S.A.F.E. (School health, Access to learning for all students, Food security, and Effective family communication) critical actions adapted to serve the needs of all students and adults in the upcoming school year. UnidosUS recognizes that leadership at the state, district, and school levels have multiple considerations for reopening schools, including family outreach, physical and mental health, operations, access to technology, and academics. Before states and districts implement their reopening plans, parents need to know the information in this report prior to sending their children back to school.