In this guide, the authors provide 5 key practices for teachers and families to support all students, including students with disabilities, at school and home. The authors identified a small number of practices that have a big impact on student learning and social-emotional-behavioral growth. These five key practices include: (1) Develop, teach, review, remind, and reinforce predictable routines and expectations; (2) Use efficient and effective instructional strategies to maximize benefit; (3) If the student has more intensive needs, provide targeted or intensive support; (4) Enhance relationships between home and school to support the student (and each other); and (5) If the student is not being successful, ask for help. This guide is intended to suggest practices that will have the biggest impact with the time educators and parents are able to dedicate to supporting learning and growth. Users of this guide should select a few key practices to focus on, and adapt them to meet their needs and their context (home or school). [This report was prepared with the National Integrated Multi-Tiered Systems of Support Research Network.]