This guide was developed to provide effective and practical strategies to meet the needs of prenatally substance-exposed children in preschool or day care settings. Techniques are based on good child development practices and are equally effective for both teachers and parents. The first chapter outlines information about prenatal substance exposure, such as the effects of different drugs on the fetus and the resulting behaviors and learning characteristics. The second chapter presents teaching strategies, including protective factors involving daily routines, transitions, and rules; facilitative factors such as relationships, peer sensitivity, and decision making; and strategies for play, communication development, motor development, social/emotional development, and home-school partnerships. Characteristics of an exemplary child development program are then described in chapter 3. Practical guidelines are offered for dealing with parents with chemical dependency in chapter 4. The final chapter focuses on assessment and offers a preschool assessment protocol consisting of a parent interview and developmental history, administration of developmental screening tests and instruments, play observation, and behavioral observations. An appendix lists organizational resources, training resources, written resources, videotapes, audiotapes, free reference materials, newsletters, and other resources; another appendix defines terms. (Each chapter contains references.) (JDD)