Historically in the United States, few people with disabilities have enrolled in science-related courses or entered scientific careers in part because high schools and colleges have not offered accessible training to this population. This document is the teaching and resource guide that accompanies a 40-minute video program in career development for junior high, high school, and adult students and their teachers and counselors. The program features female and male scientists of various ethnic backgrounds, disabilities, and lifestyles as role models. Varied science careers are represented: science teacher, computer programmer, psychiatrist, physicist, medical technologist, systems engineer, and chemistry professor. The goals of the program are to encourage students with physical or sensory impairments to consider careers in mathematics and science; and to encourage teachers, parents, and counselors to support disabled people in their efforts to achieve successful careers in these areas. Included in this guide are descriptions of the materials, a program summary, discussion questions to follow the program, a career interest checklist for students, and career summaries for each of the highlighted areas. Lists of resources for obtaining information and support concerning careers in these areas are attached. (CW)