Students enter postsecondary institutions to change their lives in some way, with degree pursuits providing opportunities to grow academically, socially, and professionally. However, significant numbers of students are unable to meet the goals they had set for themselves when they entered college. Developed by the What Works Clearinghouse™ (WWC) in conjunction with an expert panel, this guide draws upon studies of effective postsecondary student advising systems and practices. The expert panel believes the impacts of advising are magnified when advising is integrated within a broader structure of holistic student support. Holistic student support provides all students with the types and intensities of information, services, and resources they need to identify, select, and progress on the best pathway to achieve their educational and career goals. This practice guide provides four evidence-based recommendations for designing and delivering comprehensive, integrated advising to support students' educational success: (1) Intentionally design and deliver comprehensive, integrated advising that incorporates academic and non-academic supports to empower students to reach their educational goals; (2) Transform advising to focus on the development of sustained, personalized relationships with individual students throughout their college career; (3) Use mentoring and coaching to enhance comprehensive, integrated advising in ways that support students' achievement and progression; and (4) Embed positive incentives in intentionally designed advising structures to encourage student participation and continued engagement. This guide summarizes the rigorous research evidence on best practices that support its recommendations, which could help identify knowledge gaps that researchers could address in the future. [For the summary to this practice guide, see ED615137.]