The Education-to-Workforce Indicator Framework (E-W Framework), commissioned by the Bill & Melinda Gates Foundation and developed in partnership with leading experts representing more than 15 national and community organizations, is designed to encourage greater cross-sector collaboration and alignment across local, state, and national data systems by promoting the use of a common set of metrics and principles to assess and address disparities along the pre-K-to-workforce continuum. Based on a review of leading frameworks and research, together with significant input from experts, the E-W Framework offers holistic guidance for translating data into action to identify and address disparities through detailed guidance on the following: (1) Data equity principles to support ethical data use across the data life cycle; (2) Essential questions that every E-W data system should be equipped to answer; (3) Indicators that matter most along the E-W continuum for states and localities to measure; (4) Key student characteristics to inform data disaggregation; and (5) Illustrative evidenced-based practices shown to move the needle on key outcomes. Through improved data systems, policies, and practices, policymakers, administrators, practitioners, community organizations, and researchers will be better poised to support the individuals least well served by current education and workforce systems in achieving economic mobility and security. [This report was created with the Mirror Group.]