Teen pregnancy in the United States has declined significantly in the last two decades. Despite these declines, rates of teen birth, HIV, and STIs in the United States remain among the highest of any industrialized nation. Socio-economic, cultural and structural factors such as poverty, limited access to health care, racism and unemployment contribute to these high rates. Yet, behavioral interventions also show promise for helping young people reduce their risk for unwanted pregnancy, HIV and other STI. Program planners can look to the body of available evaluation and research to identify programs to help young people learn the information and skills necessary to reduce their risk. Many of these programs are best suited for implementation by community-based organizations or in after school-programs or clinics. These programs can be used to provide a foundation for sex education, yet none is comprehensive enough to stand alone in substitute for comprehensive sexual health education. Advocates for Youth recognizes however, that communities across the United States are interested in implementing evidence-informed programs that can help young people reduce their risk for unintended pregnancy, HIV and other STIs. To that end, Advocates reviewed the existing literature to identify programs with evidence of effectiveness. A description of these programs follows. [This document was prepared with assistance from Emily Bridges, Tanya Gonzalez, Laura Davis, and Debra Hauser.]