This guide has been developed through a collaborative effort involving the U.S. Environmental Protection Agency (EPA), the National Oceanic and Atmospheric Administration (NOAA), and the National Aeronautics and Space Administration (NASA). It is part of an ongoing commitment to ensure that the results of scientific research on ozone depletion are effectively applied to individual and societal decision-making. This guide is intended for use by science teachers, environmental educators, and teacher trainers in planning and conducting classes and activities on ozone depletion and also for use by individuals who conduct informal educational activities to the general public through community groups, museums, business clubs, libraries, and extension programs. It provides educators with the requisite background on the science of ozone depletion as well as lesson plans and activities. It is organized into three primary categories: background information on the science of ozone depletion, teaching activities and tools, and pamphlets describing action steps to protect the ozone layer. The materials in the guide are best-suited for high school students through college and adults, but can be adapted to meet the needs of lower grade levels. (JRH)