Although schools and school districts have experience planning for biological hazards (such as contaminated food) and types of infectious diseases (seasonal flu, Staphylococcus aureus, meningitis, etc.), pandemics often present unique challenges and greatly impact efforts to ensure continuity of teaching and learning, as well as safety. The Centers for Disease Control and Prevention (CDC) define a pandemic as a global outbreak of a new influenza A virus. Pandemics happen when new (novel) influenza A viruses emerge and have the potential to infect people easily and spread from person to person in an efficient and sustained way. This fact sheet provides school district leaders and school core planning teams with recommendations to develop or enhance an Infectious Disease Annex within an emergency operations plan (EOP) and considerations specific to pandemic planning.