The second of two related pamphlets, this guide describes how to design an outcome study and outlines procedures for collecting outcome data. After an introduction that delineates the purpose of the two-part series, the pamphlet is divided into four major sections. The first section explains how to select a cost-outcome analysis. The next three sections address the measurement of utility, benefit, and effectiveness outcome data, respectively. Each self-contained section describes (1) the outcome measure, (2) when to use the analysis, (3) strengths and limitations of the analysis, (4) an example of the analysis, (5) an assessment of the reliability and validity of the outcome data, (6) how to calculate cost-outcome ratios, and (7) how to interpret the cost-outcome ratios. A list of references is included. (TE)