Hispanic urban youth experience high levels of violence, access to drugs and alcohol, and limited access to quality educational institutions, as well as a disproportionate use of substances. However, youth exposed to multiple sources of support, such as values related to family centrality (e.g., family cohesion or "familismo") and positive social networks, are less likely to use substances, and more likely to value school and participate in community activities. The present study examines substance use and empowering-protective resources among a cohort of Hispanic students (N = 538) from a northeastern United States urban community. We also assessed the moderating influence of gender using structural equation modeling (SEM) multigroup path analysis techniques. Results indicate that access to more sociocultural resources, such as cohesive families ("familismo") and social supports, increases Hispanic adolescents' community participation and school importance. Outcomes also demonstrate the positive, yet diverging, effects of gender. Implications for community prevention and policy are discussed.