This paper presents the results of two coordinated surveys of Massachusetts adolescents, the 2007 Massachusetts Youth Risk Behavior Survey (ESE) and the Massachusetts Youth Health Survey (DPH). These two surveys were supported by funding from the Centers for Disease Control and Prevention (CDC) and administered in a random selection of 124 public secondary schools by the University of Massachusetts Center for Survey Research in the spring of 2007. Combining results from both surveys, Health and Risk Behaviors of Massachusetts Youth, 2007: The Report presents key indicators of the behavioral and health risks reported by middle school and high school youth. The report provides important information about behaviors and conditions that may compromise the health, safety, and wellbeing of young people across the Commonwealth. These behaviors include tobacco, alcohol, and other drug use; behaviors leading to injuries, such as drinking and driving, fighting, and suicide attempts; dietary behaviors and physical inactivity, and sexual behaviors that may lead to sexually transmitted disease or pregnancy. The report also discusses the prevalence of health-related conditions such as overweight, chronic disease, oral health problems, and mental health concerns among the youth. Results presented in this report show continued improvements in many important areas including tobacco use, alcohol and drug use, violent behavior, and suicidality. These improvements attest to the success of efforts by schools, community programs, healthcare workers, and families to foster the healthy development of young people in Massachusetts. Even so, despite clear successes, there are still behaviors in which improvements have not been seen, most notably nutrition and physical activity, and areas that warrant continued concern and attention. Stronger efforts to address these problems and to promote the health of all young people remain a priority. (Contains 2 footnotes and 41 figures.) [Funding for this report was supported in part by an appointment to the Applied Epidemiology Fellowship Program administered by the Council of State and Territorial Epidemiologists (CSTE) and funded by CDC's Cooperative Agreement, U60/CCU007277.]