The research study involved the introduction of the Transcendental Meditation Program® to nursing students as a strategy of self-care to reduce anxiety and stress. Nursing students are at risk for developing anxiety and stress in their academic and clinical program due to the intense learning environment that requires the integration of theoretical knowledge and clinical skills with professional responses and attitudes in highly emotional settings. (Prato & Yucha, 2013). This is the first study that investigated the efficiency of self-care intervention of the Transcendental Meditation Program® (TM) (independent variable) for reducing anxiety and stress in nursing students. The research method included feasibility and quasi-experimental studies utilizing both quantitative and qualitative (dependent variables) measures before and after the practice of Transcendental Meditation Program® for 8 weeks (about 2 months). Eight baccalaureate student nurses (BSN) from two Mid-west colleges participated in the study. Electrodermal Activity (EDA), blood pressure and pulse rate, State Trait Anxiety Inventory (STAI 1 and 2), Perceived Stress Scale (PSS), and General Self-Efficacy Scale (GSES) were measured at baseline and after 8 weeks of TM practice. Although the sample size is small, the post-test indicated significant reductions in Electrodermal Activity (EDA), State Trait Anxiety Inventory (STAI 1 and 2), Perceived Stress Scale (PSS), and General Self-Efficacy Scale (GSES). Cohen's effect size of 0.8 reflects in the effect sizes ranging from 0.783 to 1.985. There were no significant differences for the measures of systolic and diastolic blood pressure or pulse. In the qualitative measure, the participants reported that TM practice improved their motivation, confidence, compassion, and overall calmness about adjustments to college life and the nursing program challenges. The evidence from this research study with nursing students indicated the efficacy and the feasibility of integrating the Transcendental Meditation practice into the nursing curriculum to enhance physiological and psychological health. This study also indicates the value of the Transcendental Meditation practice as a self-care intervention for COVID-19 Pandemic. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]