The objective was to evaluate the impact of a psychoeducational program on the stress and quality of life of parents with a child with autism. In total, 20 parents attended a shortened version (SV group) of the program and 15 others a complete version (CV group). An assessment of perceived stress, parenting stress, and quality of life was performed before (T0), after (T1), and 6 months after the program (T2). Parental satisfaction was measured at T1. Parents in the CV group appeared to be significantly less stressed, and there was a significant improvement in certain areas of their quality of life (relationship with the child, psychological well-being, and personal fulfillment). No significant effects were observed in the SV group. Both groups highly appreciated the program. These results confirm the need to offer support to parents after receiving a diagnosis of autism for their child.