This study evaluated the effectiveness of cognitive-behavioral interventions in the treatment of persons with schizophrenia who experienced significant residual symptoms and impaired functioning despite their adherence to medication. The study used an aggregated AB single-system research design across 22 participants to evaluate change in clinical outcomes. Standardized measures of psychosocial functioning, severity of symptoms, attainment of treatment goals, and severity of the impact of illness on self-concept were used to assess change during the course of 18 months of treatment. Of the clients, 86% made statistically significant improvement in psychosocial functioning; 82% of the clients made statistically significant reduction in severity of psychiatric symptoms. All 22 clients exceeded the expected level of attainment of treatment goals. There was a statistically significant reduction in the negative impact of illness on sense of self. Findings support the effectiveness of cognitive-behavioral interventions in schizophrenia. (Contains 2 tables and 1 figure.)