This article investigates the relationship between psychological distress, acculturation, and help-seeking attitudes among people of African descent (N = 130). Psychological distress was measured using the Global Severity Index from the Brief Symptom Inventory (L. R. Derogatis & N. Melisaratos, 1983), acculturation was measured using the Measurement of Acculturation Strategies for People of African Descent (E. M. Obasi, 2005), and help-seeking attitudes were measured using the Attitudes Toward Seeking Professional Psychological Help scale (E. H. Fischer & J. I. Turner, 1970). Overall, as psychological distress increased, attitudes toward seeking professional psychological services became more negative. The negative relationship between psychological distress and confidence in therapist was significantly stronger for participants who expressed a cultural maintenance of traditional beliefs. Future directions for this body of research are discussed. (Contains 4 tables and 1 figure.)