This article explores research on clay manipulation art therapy for individuals with a diagnosis of Parkinson's disease (PD). An overview of 3 phases of the authors' previous research includes (a) comparison of people living with PD to control in a single individual setting, (b) investigation of negative psychological symptoms in a single individual setting, and (c) analysis of psychological symptoms in a 6-week group setting. Outcomes supported clay manipulation for individuals with PD, evidenced by decreased obsessive-compulsive thinking, depression, and phobic anxiety within all phases. Observed physiological changes in areas of resting tremors, gait, increased affect, and movement fluidity initiated a fourth phase of research on the interaction of sensory, kinesthetic, and neurological activity for patients living with PD.