Over a third of American college students are either overweight or obese, which has been suggested to negatively impact their academic achievement. Objective: This study seeks to better understand the relationship between body mass index (BMI) and grade point average (GPA), while examining potential mediators of this association. Participants and Methods: The sample consists of 298 college women who volunteered to complete online questionnaires between October and December 2014. Results: Although no significant differences were noted for sociodemographic variables, overweight and obese female students were found to report lower GPA and academic self-efficacy as well as higher depressive symptoms, compared with their normal-weight counterparts. Academic self-efficacy partially mediated the relationship between BMI and GPA. Conclusions: To foster better academic achievement in female college students, and especially for those who are overweight and obese, strategies for improving self-efficacy and adaptation to college should be implemented.