Staff, teachers, and students experienced rapid change as school buildings closed in March 2020 because of the spread of the novel coronavirus, COVID-19. In this brief, we use American Community Survey (ACS) data to highlight different types of challenges to remote learning and point to district and educator strategies that might mitigate harm to students as districts navigate long-term school closures. Although many families will face unique circumstances and obstacles, we focus on six factors in addition to poverty: linguistic isolation, child disability status, parents in vulnerable economic sectors, single parents, crowded conditions, and lack of computer or broadband access. We describe the difficulties each circumstance presents and potential solutions for school districts.