COVID-19 and the response to the pandemic in Oklahoma and the nation mark this as an unprecedented time in American history. Oklahoma's state system of higher education has responded to the challenges created with flexibility and innovation, transitioning more than 173,000 students to virtual, online, and alternative course delivery formats for the last half of the spring 2020 semester and for many of the public colleges and universities into the summer session, to continue to protect students, faculty, staff and visitors. This annual report reflects significant progress as a state system, ongoing commitment to excellence and innovation, and a strong partnerships within the education sector and with the business community to meet Oklahoma's evolving workforce needs. In this unprecedented fiscal climate, Oklahoma will continue to make the case that higher education is the best investment policy leaders can make to strengthen the state's economy and position Oklahoma as a top 10 state. The following contents are included in this annual report: (1) Role of the State Regents; (2) Higher Education Update; (3) Strategic Direction; (4) Higher Education in Oklahoma; (5) Academics; (6) Financial Aid; (7) Student Preparation; (8) Economic Development; (9) Fiscal; and (10) Institutional Highlights; and (11) Administrative Organization. [For the 2018 report, see ED600316.]