This study investigated the moderating roles of motivation, social engagement, and self-regulation in predicting academic achievement in grades 11-12 for 3,281 7th-9th graders. Standardized assessments of college readiness (ACT® Explore and the ACT® test) and student self-report measures of social emotional learning factors (ACT® Engage® Grades 6-9) were used in the study. The results showed that females in grades 7-9 scored higher than males for motivation and self-regulation. Motivation and social engagement moderated prior achievement in predicting later achievement in grades 11-12, while self-regulation moderated both gender and prior achievement in predicting later achievement. Specifically, among female students, effects were positive for females with higher prior achievement (PR = 95) and negative for females with lower prior achievement (PR = 5) for self-regulation in predicting achievement in grades 11-12.