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Advances in neuropsychiatry
Protein aggregates and dementia: is there a common toxicity?
  1. S Lovestone,
  2. D M McLoughlin
  1. Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
  1. Correspondence to:
    Professor S Lovestone, Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK;
    s.lovestone{at}iop.kcl.ac.uk

Abstract

This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)—β-amyloid peptide and tau—but also considers other proteins in this disorder and in less common but equally devastating diseases.

  • amyloid
  • tau
  • prion
  • synuclein
  • NFTs, neurofibrillary tangles
  • Aβ, β-amyloid
  • APP, amyloid precursor protein
  • PS1, presenilin-1
  • PS2, presenilin-2
  • APPsα, APP ectodomain
  • apoE, apolipoprotein E
  • apoE-/-, Dab1, disabled-1 intracellular adaptor protein
  • PTB, phosphotyrosine binding
  • GSK-3, glycogen synthase kinase-3
  • PrPCnormal cellular prion protein

https://doi.org/10.1136/jnnp.72.2.152

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