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Respiratory medicine
Pulmonary veno-occlusive disease: atypical presentation with unexplained exertional dyspnoea and hypoxaemia
  1. Umur Şevket Hatipoğlu1,
  2. Michael Smith1,
  3. Andrea V Arrossi2 and
  4. Adriano R Tonelli1
  1. 1Pulmonary Medicine, Cleveland Clinic, Cleveland, Ohio, USA
  2. 2Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
  1. Correspondence to Dr Umur Şevket Hatipoğlu; hatipou{at}ccf.org

Abstract

Pulmonary veno-occlusive disease is an uncommon condition that typically presents with moderate to severe pulmonary hypertension and characteristic imaging abnormalities. We report two patients who presented with severe hypoxaemia and low diffusion capacity without pulmonary hypertension and classical imaging findings. Pulmonary venoocclusive disease should be included in the differential diagnosis of unexplained hypoxemia.

  • Respiratory system
  • Pulmonary hypertension

https://doi.org/10.1136/bcr-2025-265170

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    Footnotes

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: USH, ART, MS, AVA. The following authors gave final approval of the manuscript: USH, ART, MS, AVA. USH acted as the guarantor of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.