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  • B cell depletion therapy using rituximab to induce long-term remission of recalcitrant skin lesions of subacute cutaneous lupus erythematosus

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Case Reports: Novel treatment (new drug/interventions; established drug/procedure in new situation)
B cell depletion therapy using rituximab to induce long-term remission of recalcitrant skin lesions of subacute cutaneous lupus erythematosus
  1. Nikhil Mehta1,
  2. Narayanan Baskaran1,
  3. Sudheer Arava2 and
  4. Somesh Gupta1
  1. 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
  2. 2Department of Pathology, All India Institute of Medical Sciences, New Delhi, New Delhi, Delhi, India
  1. Correspondence to Professor Somesh Gupta; someshgupta{at}aiims.edu

Abstract

A woman in her 20s presented with chilblains for 2 years and recent-onset photodistributed psoriasiform plaques. She did not have persistent good improvement despite treatment with 1 mg/kg oral prednisolone, along with successive trials with many steroid-sparing adjuvants in adequate dosage and duration, including hydroxychloroquine, methotrexate and cyclosporine, in the following 6 months. The patient had an excellent improvement and went into remission with two doses of injection rituximab, 1 g each, at a 2-week interval. The remission was maintained during the 14-month follow-up.

  • Dermatology
  • Skin

https://doi.org/10.1136/bcr-2021-248476

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    Footnotes

    • Contributors NM, NB, SA and SG contributed equally to the manuscript. SA provided the histopathology pictures and their description.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.