We discuss how organizations can foster employee well-being by developing respectful cultures, providing competent and supportive leadership, and implementing specific healthy workplace initiatives (e.g., to encourage a good life balance, create safe and healthy work practices, increase employee involvement, etc.). To provide a framework to examine how organizations can increase well-being, we use the term ‘psychologically healthy workplaces’. We identify not only how to reduce negative workplace factors (e.g., work overload), but also how to increase the positive factors (e.g., employee development). We provide examples of how organizations can create healthy workplaces through initiatives that target: (1) the way work is organized, designed, and managed (i.e., changing the organization itself); (2) the social relationships (i.e., the work groups); (3) the leaders or line managers who are responsible for worker well-being; and (4) the building of individual resources.