As one of the core techniques in 5G, the Internet of Things (IoT) is more interested than ever. Furthermore, Radio Frequency Identification (RFID) plays a crucial role in IoT development. With the extensive use of RFID, the fact that a single RFID tag integrates multiple applications has become a mainstream. To facilitate users to use the multi-application RFID tag and revoke some applications in the tag securely and efficiently, an RFID secure application revocation scheme is proposed in this paper. Users are anonymous completely in the scheme. The proposed scheme cannot only be used in multi-application RFID tag but also be used in one-application RFID tag. Furthermore, compared with other existing schemes, the scheme provides a higher level of security and has an advantage of performance.