Semantic communication is viewed as a revolutionary paradigm that can potentially transform how we design and operate wireless communication systems. However, despite a recent surge of research activities in this area, remarkably, the research landscape is still limited in at least three ways. First and foremost, the definition of a “semantic communication system” is ambiguous and varies widely between different studies. This lack of consensus makes it challenging to develop rigorous and scalable frameworks for building semantic communication networks. Secondly, current approaches to building semantic communication networks are limited by their reliance on data-driven and information-driven AI-augmented networks. These networks remain “tied” to the data, which limits their ability to perform versatile logic. In contrast, knowledge-driven and reasoning-driven AI-native networks would allow for more flexible and powerful communication capabilities. However, there is currently a lack of technical foundations to support such networks. Thirdly, the concept of “semantic representation” is not well understood yet, and its role in embedding meaning and structure in data transferred across wireless network is still a subject of active research. The development of semantic representations that are minimalist, generalizable, and efficient is critical to enabling the transmitter and receiver to generate content via a minimally semantic representation. To address these limitations, in this tutorial, we propose the first rigorous and holistic vision of an end-to-end semantic communication network that is founded on novel concepts from artificial intelligence (AI), causal reasoning, transfer learning, and minimum description length theory. We first discuss how the design of semantic communication networks requires a move from data-driven AI-augmented networks, in which wireless networks remain “tied” to data, towards reasoning-driven AI-native networks which can perform versatile ...