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Abstract
Introduction Many systematic reviews and meta-analyses (SRs/MAs) have evaluated the efficacy of biologic therapies for severe asthma. However, the overall quality of these SRs/MAs is unclear, which may influence the selection of biologics and lead to misleading clinical decisions. This umbrella review aims to objectively evaluate the overall quality of these SRs/MAs and reassess the efficacy of biologic therapies for severe asthma. Thus, this study will provide reliable evidence for clinical practice.
Methods and analysis A systematic search will be performed in PubMed, Embase, Cochrane Library, Web of Science, Scopus and conference abstracts up to 1 March 2025. Literature screening and data extraction will be conducted according to predefined inclusion and exclusion criteria. We will evaluate the reporting quality, methodological quality and evidence quality of these SRs/MAs using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, PRISMA for Network Meta-Analysis 2015 checklist, A MeaSurement Tool to Assess Systematic Reviews 2, Cochrane Risk of Bias 1.0 and Grading of Recommendations Assessment, Development and Evaluation system. Additionally, the re-analysis of outcomes will be performed using R software (V.4.3.3).
Ethics and dissemination Since this umbrella review will use publicly available data, ethics approval is not required. The results of this study will be disseminated through publication in a peer-reviewed journal.
PROSPERO registration number CRD42024607393.
- Asthma
- Protocols & guidelines
- RESPIRATORY MEDICINE (see Thoracic Medicine)
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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Footnotes
Contributors QX designed the study, submitted the registration to PROSPERO and wrote the manuscript. QX and BX completed the search strategy. QX and YH revised the language. MW is responsible for directing the overall study. MW is the guarantor.
Funding This work was supported by the National Key Research and Development Program of China (2023YFC3502602), the National Natural Science Foundation of China (82474483), the Science and Technology Innovation Team of Colleges and Universities of Henan Province (23IRTSTHN027), the Special Research Fund of National Traditional Chinese Medicine Clinical Research Base (2022JDZX046) and the Project of Science and Technology of Henan Province (232102310472).
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer-reviewed.
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