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Evidence based practice
Protocol
Key performance indicators for acute intermittent kidney replacement therapy in critically ill patients: a protocol for a systematic review
  1. Dawn Opgenorth1,
  2. Liza Bialy2,
  3. Kristin Robertson3,
  4. Samantha L Bowker3,
  5. Selvi Sinnadurai3,
  6. Jeanna Morrissey3,
  7. N Pannu4,
  8. Scott Klarenbach4,
  9. Matthew James5,
  10. Ashita Tolwani6,
  11. Michael Heung7,
  12. Javier A Neyra6,
  13. Teresa Mottes8,
  14. Fadi Hammal1,
  15. Xiaoming Wang9,
  16. Janice Y Kung10,
  17. Sean M Bagshaw1,3,
  18. Oleksa G Rewa1,3
  1. 1 Department of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada
  2. 2 Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
  3. 3 Critical Care Strategic Clinical Network of Alberta Health Services, Edmonton, Alberta, Canada
  4. 4 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
  5. 5 University of Calgary, Calgary, Alberta, Canada
  6. 6 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
  7. 7 Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
  8. 8 Ann & Robert H Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA
  9. 9 Provincial Research Data Services, Alberta Health Services, Edmonton, Alberta, Canada
  10. 10 University of Alberta, Edmonton, Alberta, Canada
  1. Correspondence to Dr Oleksa G Rewa; rewa{at}ualberta.ca

Abstract

Introduction There have been previous initiatives to identify key performance indicators (KPIs) for continuous kidney replacement therapy. However, no formal reviews of the evidence for KPIs of intermittent kidney replacement therapy (IKRT) have been conducted. This systematic review will appraise the evidence for KPIs of IKRT in critically ill patients and is part of the DIALYZING WISELY (NCT05186636) programme which aims to improve the performance of acute renal replacement therapy in intensive care units by aligning local practices with evidence-based best practices.

Methods and analysis Ovid MEDLINE, Ovid Embase, CINAHL and Cochrane Library will be searched for studies involving KPIs for IKRT. Grey literature will also be searched and include technical reports, practice guidelines and conference proceedings as well as websites of relevant organisations. We will search the Agency of Healthcare Research and National Quality Measures Clearinghouse for IKRT-related KPIs. Studies will be included if they contain KPIs, occur in critically ill patients and are associated with IKRT. We will evaluate the risk of bias using the modified Cochrane tool and certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations methodology. The analysis will be primarily descriptive. Each KPI will be evaluated for importance, scientific acceptability, usability and feasibility using the four criteria proposed by the United States Strategic Framework Board for a National Quality Measurement and Reporting System. Finally, KPIs will be appraised for potential operational characteristics, potential to be integrated into electronic medical records, adoptability by stakeholders and affordability, if applicable.

Ethics and dissemination Ethics approval is not required as primary data will not be collected. Findings of this review will be disseminated through peer-related publication.

PROSPERO registration number CRD42022074444.

  • Systematic Review
  • Meta-Analysis
  • Adult intensive & critical care
  • Acute renal failure
  • Dialysis
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2024-093334

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    Footnotes

    • X @janicekung

    • Contributors DO contributed to the study protocol development and drafting of the manuscript. KR, SLB, SS, JM, NP, SK, MJ, AT, MH, JAN, TM, FH, XW, JYK, SMB and OR contributed to the study protocol development and critical revision of the manuscript. SMB and OR conceived the study, developed the protocol and contributed to the development and drafting of the manuscript. All of the authors approved the final version to be published. OR is the guarantor of this manuscript.

    • Funding Funding is provided by Alberta Innovates Partnership for Research and Innovation in the Health System (PRIHS) and the Critical Care Strategic Clinical Network of Alberta Health Services.

    • Disclaimer The funder had no role in development of the study protocol, drafting of the manuscript or decision to submit the work for publication.

    • Competing interests OR has received consulting honoraria from Baxter Healthcare Inc. and Leadiant Biosciences. SMB is supported by a Canadian Research Chair in Critical Care Nephrology. JAN has received consulting honoraria from Baxter Healthcare Inc. and Leadiant Biosciences. MH serves as a consultant for Wolters Kluwer Inc. and Potrero Inc., and has received research funding support from Spectral Medial Inc. and Astute Medical Inc.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.