You are here

  • Home
  • Archive
  • Volume 14, Issue 8
  • Prognostic prediction models for treatment experienced people living with HIV: a protocol for systematic review and meta-analysis

Article Text

Article menu
Epidemiology
Protocol
Prognostic prediction models for treatment experienced people living with HIV: a protocol for systematic review and meta-analysis
  1. Xinsheng Wu1,
  2. Yuanyi Chen2,3,
  3. Zhen Lu2,3,
  4. Junfeng Wang4,
  5. Huachun Zou1,5,6
  1. 1School of Public Health, Fudan University, Shanghai, China
  2. 2Shenzhen Campus of Sun Yat-sen University, Shenzhen, China
  3. 3School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China
  4. 4Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
  5. 5School of Public Health, Southwest Medical University, Luzhou, China
  6. 6Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
  1. Correspondence to Professor Huachun Zou; zouhuachun{at}fudan.edu.cn

Abstract

Introduction Despite the favourable efficacy of antiretroviral therapy (ART), HIV/AIDS continues to impose significant disease burdens worldwide. This study aims to systematically review published prognostic prediction models for survival outcomes of treatment experienced people living with HIV (TE-PLHIV), to describe their characteristics, compare their performance and assess the risk of bias and real-world clinical utility.

Methods and analysis Studies will be identified through a comprehensive search in PubMed, EMBASE, Scopus, the Cochrane Library, and OpenGrey databases. Two reviewers will independently conduct a selection of eligible studies, data extraction and critical appraisal. Included studies will be systematically summarised using appropriate tools designed for prognostic prediction modelling studies. Where applicable, evidence will be summarised with meta-analyses.

Ethics and dissemination Ethical approval is not required because only available published data will be analysed. The results of this work will be published in a peer-reviewed journal.

Systematic review registration PROSPERO registration number CRD42023412118.

  • HIV & AIDS
  • THERAPEUTICS
  • EPIDEMIOLOGY
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2023-081129

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Supplementary materials

    • Supplementary Data

      This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

    Footnotes

    • Contributors HZ conceived and designed the protocol with JW and XW. XW and YC contributed to the manuscript with all authors (XW, YC, ZL, JW and HZ) critically revising the manuscript. All authors have read and approved the final version of the manuscript. HZ is the guarantor.

    • Funding This study was supported by the Natural Science Foundation of China Excellent Young Scientists Fund (82022064). The funding parties did not have any role in the design of the study or in the explanation of the data.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.