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  • Methodological quality of research on perioperative immunomodulatory supplementation in oncological gastrointestinal tract surgery: a meta-research protocol

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Nutrition and metabolism
Protocol
Methodological quality of research on perioperative immunomodulatory supplementation in oncological gastrointestinal tract surgery: a meta-research protocol
  1. Luana Pucci de Lima1,
  2. Arthur Thives Mello1,
  3. Giovanna Mozzaquattro Nascimento1,
  4. Erasmo B S de Moraes Trindade1,2
  1. 1Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil
  2. 2Department of Nutrition, Federal University of Santa Catarina, Florianopolis, Brazil
  1. Correspondence to Luana Pucci de Lima; nutriluanap{at}hotmail.com

Abstract

Introduction One of the topics that show differences of opinion in the scientific field of nutrition is the recommendation by clinical practice guidelines (CPGs) of an immunomodulatory diet with arginine, nucleotides and omega-3 for individuals diagnosed with cancer undergoing major surgery. The quality of the recommendations is directly related to credibility, transparency and rigour in their development, but also to the quality of the studies published and available for inclusion in the recommendation, such as systematic reviews (SRs) and randomised clinical trials. The aim of this study is to evaluate the methodological quality of the recommendation of perioperative immunomodulatory supplementation for individuals with gastrointestinal and head and neck cancer, the CPGs, and the studies that support the recommendations.

Methods and analysis We will conduct a systematic search for CPGs. Recommendations for nutritional supplementation with immunomodulatory substrates for individuals undergoing major oncological surgery will be analysed using the Appraisal of Guidelines Research and Evaluation-Recommendations Excellence tool. CPGs will be analysed using the Appraisal of Guidelines Research and Evaluation II tool. The SRs cited in the recommendations will be analysed using the A Measurement Tool to Assess Systematic Reviews II tool and additional questions regarding heterogeneity in reviews. The clinical trials cited in the SRs and in the guideline recommendations (when applicable) will be analysed according to questions regarding heterogeneity in trials. The results will be presented in tables or charts using descriptive analyses.

Ethics and dissemination The results of this study will be disseminated through relevant conferences and peer-reviewed journals.

Protocol registration number 10.17605/OSF.IO/X2GYT.

  • NUTRITION & DIETETICS
  • EPIDEMIOLOGY
  • Protocols & guidelines
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2023-082112

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    Footnotes

    • X @arthurthives

    • Contributors LPdL: conceptualisation, methodology, writing - original draft preparation, writing - review and editing. ATM: conceptualisation, methodology, writing - review and editing. GMN: conceptualisation, methodology, writing - review and editing. EBSdMT: conceptualisation, methodology, writing - review and editing.

    • Funding This work is supported by the Brazilian Coordination for the Improvement of Higher Education Personnel – CAPES scholarship (process number 164700/2015-3). The funding source did not influence the content of this study.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.