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Dentistry and oral medicine
Protocol
Botulinum toxin for the management of bruxism: an overview of reviews protocol
  1. Manuella Salm Coelho1,
  2. Júlia Meller Dias de Oliveira1,
  3. Helena Polmann2,
  4. Patrícia Pauletto3,
  5. Cristine Miron Stefani4,
  6. Lara Catarine De Luca Maciel5,
  7. Graziela De Luca Canto1
  1. 1Department of Dentistry, University of Santa Catarina, Florianópolis, Brazil
  2. 2Federal University of Santa Catarina, Florianopolis, Brazil
  3. 3Facultad de Odontología, Universidad de Las Americas, Quito, Ecuador
  4. 4Department of Dentistry, University of Brasilia, Brasilia, Federal District, Brazil
  5. 5Queen Mary University of London, London, UK
  1. Correspondence to Dr Patrícia Pauletto; patricia.pauletto{at}udla.edu.ec

Abstract

Introduction Bruxism is characterised by a repetitive activity in the masticatory muscles that involves teeth clenching or grinding and/or forceful mandibular movements. Its management is typically initiated when individuals start experiencing the adverse effects of the condition. One of the available intervention forms is the administration of botulinum toxin type A (BoNT-A). Numerous systematic reviews have addressed the use of BoNT-A to manage bruxism; however, the results are controversial. The current overview aims to determine BoNT-A’s effectiveness for managing bruxism in relation to placebo, the absence of treatment or alternative interventions in the adult population.

Methods and analysis This study will include systematic reviews (SRs), with or without meta-analysis, aiming to evaluate the efficacy of BoNT-A for bruxism in adults. A broad literature search will be carried out on Cochrane Library, EMBASE, LILACS, Livivo, PubMed/MEDLINE, Scopus, Web of Science and the grey literature. Experts in the topic and reference lists of included SRs will also be consulted. The study selection will be conducted in two phases by two independent reviewers. Data collection will be performed by one author and cross-checked by another. The methodological quality of included SRs will be evaluated using AMSTAR-II. A narrative synthesis will be employed as the formal method to combine individual study data. The overlap across studies will be quantified by the corrected covered area and illustrated by the Graphical Representation of Overlap for Overviews.

Ethics and dissemination This overview does not require ethics approval, as it uses secondary data from previously published studies. The results will be disseminated through the publication in a high-impact journal.

OSF of registration DOI: 10.17605/OSF.IO/RB45T.

  • EPIDEMIOLOGY
  • ORAL MEDICINE
  • PAIN MANAGEMENT
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2023-082861

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    Footnotes

    • Contributors This protocol was carefully produced, concluded, reviewed and approved with the communion of all authors. MSC worked on study conceptualisation, study design, data collection, data analysis and the initial manuscript draft and approved the final manuscript as submitted. JMDdO worked on study conceptualisation, study design and data collection and approved the final manuscript as submitted. HP worked on study conceptualisation, study design and data collection and approved the final manuscript as submitted. PP worked on study conceptualisation, study design, data collection and data analysis and approved the final manuscript as submitted. CMS worked on study conceptualisation, study design and data collection and approved the final manuscript as submitted. LCDLM worked on study conceptualisation, study design, data analysis and the manuscript critical revision and approved the final manuscript as submitted. GDLC worked on study conceptualisation, data analysis and the critical manuscript revision and approved the final manuscript as submitted. Guarantor: GDLC.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.