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Abstract
Peutz-Jeghers syndrome is an autosomal dominant inherited disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Peutz-Jeghers syndrome has an incidence of approximately 1 in 25,000 to 300,000 births. Crohn's disease is a chronic inflammatory bowel disease that typically manifests as regional enteritis with its incidence ranging from 3.1 to 14.6 cases per 100,000 person-years in North America. Herein, we report a case of a 30-year-old male patient who had both Peutz-Jeghers syndrome and Crohn's disease. We believe that this is the first case in Korea and the second report in the English literatures on Peutz-Jeghers syndrome coincidentally accompanied by Crohn's disease.
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References
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 | Fig. 2.Endoscopic findings. (A) Multiple polyps of variable sizes are observed in the stomach. Longitudinal ulcer (B) and hamartomatous polyps (C) are also found in the colon. |
 | Fig. 3.(A) Histologic examination of a resected polyp demonstrates branching bundles of smooth muscle fibers covered by hyperplastic mucosa compatible with hamartoma which is typical of a Peutz-Jeghers syndrome polyp (H&E, ×10). (B) Chronic inflammatory lesion with granuloma (arrow), suggestive Crohn's disease, is also observed (H&E, ×100). |
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