Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Tubulointerstitial Nephritis and Primary Biliary Cirrhosis with a T Cell-dominant Profile of Infiltrating Cells and Granulomas in Both Organs
Takamasa Iwakura, Yoshihide Fujigaki, Takashi Matsuyama, Tomoyuki Fujikura, Naro Ohashi, Hideo Yasuda, Akihiko Kato, Satoshi Baba
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Keywords: interstitial nephritis, granuloma, primary biliary cirrhosis
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2013 Volume 52 Issue 4 Pages 467-471

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Abstract
A 46-year-old woman was admitted to our hospital for an evaluation of progressive renal insufficiency and elevated liver enzymes. A renal biopsy revealed chronic granulomatous interstitial nephritis. Her laboratory findings indicated primary biliary cirrhosis (PBC), which was confirmed with a liver biopsy. CD4+ T cells and CD8+ T cells with granuloma formation were the predominant cells infiltrating into the interstitium of the kidneys and liver. The etiology of tubulointerstitial nephritis in the present patient was not clear; however, it might have shared the same pathogenesis as PBC due to the relatively close onset, the similar profiles of infiltrating cells and the presence of granulomas.
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© 2013 by The Japanese Society of Internal Medicine
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