Abstract
Background: The effects of carbohydrate-restricted (ketogenic) diets on metabolic parameters in children have been incompletely assessed.
Objective: To compare the efficacy and metabolic impact of ketogenic and hypocaloric diets in obese children and adolescents.
Subjects: Fifty-eight obese subjects were placed on one of the two diets for 6 months.
Methods: Anthropometric measurements, body composition, oral glucose/insulin tolerance test, lipidemic profile, high molecular weight (HMW) adiponectin, whole-body insulin sensitivity index (WBISI), and homeostatic model assessment-insulin resistance (HOMA-IR) were determined before and after each diet.
Results: Both groups significantly reduced their weight, fat mass, waist circumference, fasting insulin, and HOMA-IR (p=0.009 for ketogenic and p=0.014 for hypocaloric), but the differences were greater in the ketogenic group. Both groups increased WBISI significantly, but only the ketogenic group increased HMW adiponectin significantly (p=0.025).
Conclusions: The ketogenic diet revealed more pronounced improvements in weight loss and metabolic parameters than the hypocaloric diet and may be a feasible and safe alternative for children’s weight loss.
©2012 by Walter de Gruyter Berlin Boston
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- Masthead
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- Reviews
- 18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
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- Overestimation of final height prediction in patients with classical congenital adrenal hyperplasia using the Bayley and Pinneau method
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- Association of vitamin D receptor gene Cdx2 polymorphism with bone markers in Turner syndrome patients
- Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents
- Assessment of the 21-hydroxylase deficiency and the adrenal functions in young females with Turner syndrome
- The association of FGF23 levels in obese adolescents with insulin sensitivity
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- Foster care and type 1 diabetes in the Bronx: a case series
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- Letter to the editor
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- Meetings
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