Postsynaptic effects of Aplysia cysteine-rich neurotrophic factor in the induction of activity-dependent long-term facilitation in Aplysia californica
- 1Neuroscience Institute, New York University School of Medicine, New York, New York 10016, USA
- 2Center for Neural Science, New York University, New York, New York 10003, USA
- Corresponding author: tc71{at}nyu.edu
Abstract
The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of Aplysia cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term facilitation (AD-LTF) at sensory-to-motor neuron synapses that mediate defensive reflexes in Aplysia. We found that ApCRNF signaling is required for the induction of AD-LTF, and for training-induced early protein kinase activation and late forms of gene expression, exclusively in postsynaptic neurons. These results support the view that ApCRNF is critically involved in AD-LTF at least in part through postsynaptic mechanisms.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.051011.119.
- Received October 4, 2019.
- Accepted December 18, 2019.
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