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Risk of metformin use in patients with T2DM and advanced CKD

Nature Reviews Endocrinology volume 11, pages 697–699 (2015)Cite this article

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In a new study published in The Lancet Diabetes & Endocrinology, metformin use is associated with significantly increased all-cause mortality in patients with type 2 diabetes mellitus and stage 5 chronic kidney disease (CKD). The findings support current recommendations that metformin should not be used in patients with stage 5 CKD.

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References

  1. Schernthaner, G. & Schernthaner, G. H. In Pharmacotherapy of Diabetes: New Developments (ed. Mogensen, C. E.) 77–86 (Springer, 2007).

    Book  Google Scholar 

  2. Hung, S.-C. et al. Metformin use and mortality in patients with advanced chronic kidney disease: national, retrospective, observational, cohort study. Lancet Diabetes Endocrinol. 3, 605–614 (2015).

    Article  CAS  Google Scholar 

  3. Chowdhury, T. A., Wright, R. & Yaqoob, M. M. Using metformin in the presence of renal disease. BMJ http://dx.doi.org/10.1136/bmj.h1758.

  4. Inzucchi, S. E., Lipska, K. J., Mayo, H., Bailey, C. J. & McGuire, D. K. Metformin in patients with type 2 diabetes and kidney disease: a systematic review. JAMA 312, 2668–2675 (2014).

    Article  Google Scholar 

  5. Roussel, R. et al. Metformin use and mortality among patients with diabetes and atherothrombosis. Arch. Intern. Med. 170, 1892–1899 (2010).

    Article  CAS  Google Scholar 

  6. Ekström, N. et al. Effectiveness and safety of metformin in 51,675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register. BMJ Open 2, e001076 (2012).

    Article  Google Scholar 

  7. Lalau, J. D., Arnouts, P., Sharif, A. & De Broe, M. E. Metformin and other antidiabetic agents in renal failure patients. Kidney Int. 87, 308–322 (2015).

    Article  CAS  Google Scholar 

  8. Stanton, R. C. Metformin use in type 2 diabetes mellitus with CKD: is it time to liberalize dosing recommendations? Am. J. Kidney Dis. 66, 193–195 (2015).

    Article  CAS  Google Scholar 

  9. Penfornis, A., Blicklé, J. F., Fiquet, B., Quéré, S. & Dejager, S. How are patients with type 2 diabetes and renal disease monitored and managed? Insights from the observational OREDIA study. Vasc. Health Risk Manag. 10, 341–352 (2014).

    PubMed  PubMed Central  Google Scholar 

  10. Duong, J. K. et al. The role of metformin in metformin-associated lactic acidosis (MALA): case series and formulation of a model of pathogenesis. Drug Saf. 36, 733–746 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine 1, Rudolfstiftung Hospital, Juchgasse 25, Vienna, 1030, Austria

    Guntram Schernthaner

  2. Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18–20, Vienna, 1090, Austria

    Marie Helene Schernthaner-Reiter

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  1. Guntram Schernthaner
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  2. Marie Helene Schernthaner-Reiter
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Correspondence to Guntram Schernthaner.

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Competing interests

G.S. has served on advisory boards for Astra Zeneca, Boehringer Ingelheim, Bristol–Myers Squibb, Eli Lilly, Johnston & Johnston and Takeda, and has served as a speaker for Astra Zeneca, Boehringer Ingelheim, Bristol–Myers Squibb, Eli Lilly, Merck, Novo Nordisk, Sanofi and Takeda. M.H.S.-R. declares no competing interests.

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Schernthaner, G., Schernthaner-Reiter, M. Risk of metformin use in patients with T2DM and advanced CKD. Nat Rev Endocrinol 11, 697–699 (2015). https://doi.org/10.1038/nrendo.2015.132

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