A new study reports that susceptibility to drug-induced liver injury by the cyclooxygenase 2 (COX-2) inhibitor lumiracoxib is associated with a human lymphocyte antigen (HLA) class II haplotype. This finding suggests that those at risk of hepatotoxicity can be identified by HLA genotyping, raising the possibility that lumiracoxib can be resurrected as a useful drug.
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A.K.D. received funding from AstraZeneca and the International Serious Adverse Events Consortium. A.K.D. also consulted with Johnson and Johnson.
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Aithal, G., Daly, A. Preempting and preventing drug-induced liver injury. Nat Genet 42, 650–651 (2010). https://doi.org/10.1038/ng0810-650
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DOI: https://doi.org/10.1038/ng0810-650
